Replication-born double-strand break repair via sister chromatid exchange

Across TCGA cell cohorts, RNA activity of the Replication-born double-strand break repair via sister chromatid exchange pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP57L1, RAB23, and TMEM242, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CEP57L1 grouped by Replication-born double-strand break repair via sister chromatid exchange-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	CEP57L1 →	-1.117	-2.411	.004	<.001	3	5
KIDNEY	RAB23 →	-1.074	-2.353	.008	<.001	3	4
KIDNEY	TMEM242 →	-0.799	-2.181	.002	<.001	3	4
OESOPHAGUS	PCMT1 →	-0.732	-0.214	.004	<.001	2	4
KIDNEY	OSBPL6 →	-1.364	-1.504	.005	.007	3	3
SKIN	PATZ1 →	+0.952	+0.327	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CEP57L1 by Replication-born double-strand break repair via sister chromatid exchange activity — KIDNEY

Explore this box plot interactively →