Replication-born double-strand break repair via sister chromatid exchange

Across TCGA cell cohorts, RNA activity of the Replication-born double-strand break repair via sister chromatid exchange pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BRIX1, RPL37, and NUP155, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BRIX1 grouped by Replication-born double-strand break repair via sister chromatid exchange-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BRIX1 →	-0.264	-0.157	.006	.001	3	6
LUNG_NSCLC_LUAD	RPL37 →	-0.313	-0.169	<.001	<.001	3	5
LUNG_SCLC	NUP155 →	-0.325	-0.161	<.001	.001	3	5
OESOPHAGUS	SERPINB10 →	-0.113	-0.193	.006	.001	3	5
LARGE_INTESTINE	WNT10B →	+0.160	+0.079	.007	.007	2	6
URINARY_TRACT	PARP6 →	+0.315	+0.261	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BRIX1 by Replication-born double-strand break repair via sister chromatid exchange activity — LUNG_SCLC

Explore this box plot interactively →