Hyaloid vascular plexus regression

Across TCGA patient cohorts, RNA activity of the Hyaloid vascular plexus regression pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PCSK2, TMEM35A, and GFOD1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaloid vascular plexus regression activity versus PCSK2 in GBM (Pearson r = 0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PCSK2 →	+1.643	+0.242	<.001	<.001	3	3
GBM	TMEM35A →	+1.176	+0.156	<.001	<.001	3	3
GBM	GFOD1 →	+0.618	+0.222	<.001	<.001	3	3
GBM	SLC45A3 →	+0.961	+0.307	<.001	<.001	3	3
GBM	MC4R →	+0.248	+0.194	<.001	.002	3	3
GBM	KCNK3 →	+0.514	+0.206	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990384 vs PCSK2 — GBM

Explore this scatter interactively →