Hyaloid vascular plexus regression

Across TCGA cell cohorts, RNA activity of the Hyaloid vascular plexus regression pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR52I2, RAPH1, and EGR1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR52I2 grouped by Hyaloid vascular plexus regression-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR52I2 →	+0.141	+2.020	.004	.003	3	4
SOFT_TISSUE	RAPH1 →	+0.348	+2.164	.003	.001	3	3
LUNG_SCLC	EGR1 →	+0.161	+1.846	.005	.002	3	3
UPPER_AERODIGESTIVE_TRACT	COMT →	-0.244	-0.270	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	OR1I1 →	-0.321	-0.226	.004	.007	3	3
UPPER_AERODIGESTIVE_TRACT	GUK1 →	-0.158	-0.208	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR52I2 by Hyaloid vascular plexus regression activity — OESOPHAGUS

Explore this box plot interactively →