Hyaloid vascular plexus regression

Across TCGA cell cohorts, RNA activity of the Hyaloid vascular plexus regression pathway is significantly associated with the protein abundance of multiple proteins, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ARPC5L, GUK1, and PPP4R2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hyaloid vascular plexus regression activity versus ARPC5L in LUNG_SCLC (Pearson r = 0.70).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARPC5L →	+1.030	+1.563	.009	.005	1	1
LUNG_SCLC	GUK1 →	+0.836	+1.899	.003	.003	1	1
LUNG_SCLC	PPP4R2 →	+0.730	+1.673	.003	.004	1	1
LUNG_SCLC	TUB →	+0.676	+1.563	.004	.005	1	1
LUNG_SCLC	HMGB1 →	+0.975	+1.787	.001	.002	1	1
LUNG_SCLC	PHACTR4 →	+1.638	+1.496	.006	.002	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990384 vs ARPC5L — LUNG_SCLC

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