Hyaloid vascular plexus regression

Across TCGA cell cohorts, RNA activity of the Hyaloid vascular plexus regression pathway is significantly associated with the drug response of multiple features, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are BX-912, RU-SKI 43, and TGX221, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BX-912 grouped by Hyaloid vascular plexus regression-low versus -high activity in LUNG_SCLC.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	BX-912 →	-0.934	-1.556	.009	.012	3	1
LUNG_SCLC	RU-SKI 43 →	+0.396	+1.012	.003	.038	2	2
LUNG_SCLC	TGX221 →	+0.594	+1.119	.009	.046	3	1
LUNG_SCLC	TW 37 →	-0.184	-1.826	.025	.045	1	1
LUNG_SCLC	HKMTI-1-005 →	-0.485	-1.826	.029	.045	1	1
LUNG_SCLC	ICL-SIRT078 →	-0.850	-1.826	.034	.045	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BX-912 by Hyaloid vascular plexus regression activity — LUNG_SCLC

Explore this box plot interactively →