Lipid transport across blood-brain barrier

Across TCGA patient cohorts, RNA activity of the Lipid transport across blood-brain barrier pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FABP5, SNRNP70, and MORF4L2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid transport across blood-brain barrier activity versus FABP5 in HNSC (Pearson r = 0.51).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FABP5 →	+0.772	+0.066	<.001	<.001	3	7
OV	SNRNP70 →	-0.563	-0.073	.004	.001	3	7
LSCC	MORF4L2 →	-0.297	-0.075	.005	<.001	3	7
OV	SMNDC1 →	-0.362	-0.086	.001	.001	3	6
BRCA	CD36 →	+1.210	+0.082	<.001	<.001	3	6
GBM	CDC5L →	-0.213	-0.083	.005	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990379 vs FABP5 — HNSC

Explore this scatter interactively →