Lipid transport across blood-brain barrier

Across TCGA patient cohorts, RNA activity of the Lipid transport across blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SERPINE1, SVEP1, and TMEM255B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid transport across blood-brain barrier activity versus SERPINE1 in OV (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SERPINE1 →	+1.419	+0.084	.005	.005	3	6
OV	SVEP1 →	+1.188	+0.109	.001	.001	3	6
HNSC	TMEM255B →	+0.521	+0.158	.009	<.001	3	6
UCEC	DCLK2 →	+0.538	+0.109	<.001	.003	3	6
CCRCC	COLEC12 →	+1.223	+0.149	<.001	<.001	3	6
LSCC	SPI1 →	+0.422	+0.068	.002	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990379 vs SERPINE1 — OV

Explore this scatter interactively →