Lipid transport across blood-brain barrier

Across TCGA cell cohorts, RNA activity of the Lipid transport across blood-brain barrier pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FABP5, UNC13D, and CA2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Lipid transport across blood-brain barrier activity versus FABP5 in BREAST (Pearson r = 0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	FABP5 →	+3.071	+1.255	.008	.007	1	8
LIVER	UNC13D →	-4.433	-1.909	.001	<.001	3	5
OESOPHAGUS	CA2 →	+2.757	+1.759	.001	.002	3	4
LARGE_INTESTINE	SENP6 →	+1.439	+1.596	<.001	.001	3	4
LARGE_INTESTINE	GTF2H2C →	+0.975	+1.092	.001	.001	3	4
BREAST	TUBGCP4 →	+0.848	+1.245	.001	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990379 vs FABP5 — BREAST

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