Gap junction-mediated intercellular transport

Across TCGA cell cohorts, RNA activity of the Gap junction-mediated intercellular transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OPTN, HDDC2, and PGAP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OPTN grouped by Gap junction-mediated intercellular transport-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OPTN →	-1.576	-1.030	<.001	.007	3	4
SOFT_TISSUE	HDDC2 →	+0.808	+1.606	.001	.004	3	4
SOFT_TISSUE	PGAP1 →	+0.984	+1.500	.003	<.001	3	4
SOFT_TISSUE	ZFP2 →	+0.820	+1.684	.001	.002	3	4
LARGE_INTESTINE	MDM2 →	+1.159	+1.475	<.001	<.001	3	4
BLOOD_Leukemia	SREK1IP1 →	+0.966	+1.175	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OPTN by Gap junction-mediated intercellular transport activity — LUNG_SCLC

Explore this box plot interactively →