Gap junction-mediated intercellular transport

Across TCGA cell cohorts, RNA activity of the Gap junction-mediated intercellular transport pathway is significantly associated with the shRNA dependency of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FAM83H, MAGEB5, and LINC01123, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FAM83H grouped by Gap junction-mediated intercellular transport-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FAM83H →	+0.093	+1.477	.003	.003	3	4
OVARY	MAGEB5 →	+0.235	+1.472	.003	.002	3	4
LUNG_NSCLC_LUSC	LINC01123 →	-0.270	-1.719	.002	.002	3	3
BLOOD_Myeloma	AP2S1 →	+0.434	+1.695	.003	.002	3	3
URINARY_TRACT	OGDHL →	+0.280	+2.305	.003	<.001	3	3
SOFT_TISSUE	BCL2L13 →	+0.158	+1.529	.003	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FAM83H by Gap junction-mediated intercellular transport activity — OESOPHAGUS

Explore this box plot interactively →