Cellular response to insulin-like growth factor stimulus

Across TCGA patient cohorts, RNA activity of the Cellular response to insulin-like growth factor stimulus pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPIAL4G, LRRK2-DT, and UBL3, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to insulin-like growth factor stimulus activity versus PPIAL4G in BRCA (Pearson r = -0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	PPIAL4G →	-0.224	-0.121	.003	.002	3	3
CCRCC	LRRK2-DT →	+0.960	+0.121	<.001	<.001	3	3
LUAD	UBL3 →	+0.335	+0.113	.007	.004	3	3
LUAD	C1QTNF7 →	+0.541	+0.100	.004	.002	3	3
BRCA	GCSAML →	+0.410	+0.148	<.001	<.001	3	3
LUAD	SNHG17 →	-0.477	-0.112	.005	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990314 vs PPIAL4G — BRCA

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