Neutrophil migration

Across TCGA patient cohorts, RNA activity of the Neutrophil migration pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1_S351, RIN3, and SAMSN1_S23, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil migration activity versus RCSD1_S351 in OV (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RCSD1_S351 →	+0.884	+0.053	<.001	<.001	3	10
COAD	RIN3 →	+0.540	+0.036	<.001	<.001	3	10
GBM	SAMSN1_S23 →	+0.894	+0.083	<.001	<.001	3	10
OV	SASH3 →	+0.552	+0.058	<.001	<.001	3	10
GBM	SKAP2 →	+0.736	+0.093	<.001	<.001	3	10
OV	SPN →	+0.818	+0.047	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990266 vs RCSD1_S351 — OV

Explore this scatter interactively →