Neutrophil migration

Across TCGA patient cohorts, RNA activity of the Neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PIK3R5, MEFV, and BIN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil migration activity versus PIK3R5 in GBM (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIK3R5 →	+0.967	+0.217	<.001	<.001	3	9
LSCC	MEFV →	+0.720	+0.221	<.001	<.001	3	8
LSCC	BIN2 →	+0.780	+0.211	<.001	<.001	3	8
LSCC	CSF3R →	+1.072	+0.210	<.001	<.001	3	8
LSCC	WAS →	+0.683	+0.204	<.001	<.001	3	8
GBM	SLA →	+0.993	+0.159	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990266 vs PIK3R5 — GBM

Explore this scatter interactively →