Neutrophil migration

Across TCGA cell cohorts, RNA activity of the Neutrophil migration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPHX1, DYM, and NPTN, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Neutrophil migration activity versus EPHX1 in BLOOD_Leukemia (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPHX1 →	+0.851	+0.166	.005	.004	3	6
CNS	DYM →	+0.635	+0.183	.005	.007	3	5
LIVER	NPTN →	+1.041	+0.215	.004	.001	3	5
KIDNEY	RTL8A →	+0.995	+0.301	.008	.002	3	5
LARGE_INTESTINE	CEP350 →	+0.844	+0.250	.001	.001	3	5
BLOOD_Lymphoma	CD63 →	+1.990	+0.202	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990266 vs EPHX1 — BLOOD_Leukemia

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