Cellular response to leucine starvation

Across TCGA patient cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PIP4K2A, PRKG1, and TNS2, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leucine starvation activity versus PIP4K2A in GBM (Pearson r = 0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PIP4K2A →	+0.451	+0.045	.005	.009	3	8
CCRCC	PRKG1 →	+0.603	+0.040	<.001	.002	3	8
BRCA	TNS2 →	+0.369	+0.054	<.001	<.001	3	8
BRCA	RFC3 →	-0.279	-0.064	<.001	<.001	3	7
GBM	ATAD2_S327 →	-0.864	-0.087	<.001	<.001	3	7
GBM	UTRN →	+0.418	+0.081	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990253 vs PIP4K2A — GBM

Explore this scatter interactively →