Cellular response to leucine starvation

Across TCGA patient cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNU4-8P, PHC2-AS1, and KRBA2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leucine starvation activity versus RNU4-8P in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU4-8P →	+0.588	+0.409	<.001	.001	3	4
GBM	PHC2-AS1 →	+0.639	+0.597	.001	.001	3	4
COAD	KRBA2 →	+0.346	+0.509	<.001	.004	3	3
BRCA	LRRC17 →	+1.117	+0.463	<.001	.002	3	3
UCEC	TVP23BP2 →	+0.689	+0.594	.004	.001	3	3
UCEC	PPP1R14C →	-0.856	-0.665	.009	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990253 vs RNU4-8P — BRCA

Explore this scatter interactively →