Cellular response to leucine starvation

Across TCGA patient cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ATF2_S136, SPEN_T2460, and TP53BP1_S63, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cellular response to leucine starvation activity versus ATF2_S136 in GBM (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ATF2_S136 →	+0.723	+0.758	<.001	<.001	3	4
OV	SPEN_T2460 →	+1.612	+0.432	<.001	<.001	3	3
GBM	TP53BP1_S63 →	+0.740	+1.090	.001	<.001	3	3
UCEC	KLC2_S179 →	-1.543	-0.917	<.001	<.001	3	3
BRCA	MEFV_S242 →	-1.272	-0.893	<.001	<.001	3	3
COAD	RERE_S613 →	-0.487	-0.651	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990253 vs ATF2_S136 — GBM

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