Cellular response to leucine starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP1M1, CEP68, and ASB13, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AP1M1 grouped by Cellular response to leucine starvation-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	AP1M1 →	-0.618	-0.217	.008	.007	3	4
LUNG_NSCLC_LUAD	CEP68 →	-0.609	-0.198	.009	.004	3	4
STOMACH	ASB13 →	-1.546	-0.462	<.001	<.001	3	4
PANCREAS	DMPK →	-1.037	-0.213	.002	.008	3	3
BONE	EPC1 →	-1.339	-0.423	.004	.001	3	3
LARGE_INTESTINE	GGH →	+1.102	+0.383	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AP1M1 by Cellular response to leucine starvation activity — OESOPHAGUS

Explore this box plot interactively →