Cellular response to leucine starvation

Across TCGA cell cohorts, RNA activity of the Cellular response to leucine starvation pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACYP2, APC, and PPIG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ACYP2 grouped by Cellular response to leucine starvation-low versus -high activity in BLOOD_Myeloma.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	ACYP2 →	+0.200	+0.321	.003	<.001	3	3
LUNG_SCLC	APC →	-0.209	-0.902	.009	.004	3	3
LUNG_SCLC	PPIG →	+0.166	+1.324	.009	.005	3	3
LUNG_SCLC	SLC13A5 →	+0.158	+1.019	.004	.002	3	3
LUNG_SCLC	MTNR1A →	-0.235	-1.393	<.001	<.001	3	3
SKIN	KRT36 →	+0.124	+0.172	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ACYP2 by Cellular response to leucine starvation activity — BLOOD_Myeloma

Explore this box plot interactively →