Protein localization to nucleoplasm

Across TCGA patient cohorts, RNA activity of the Protein localization to nucleoplasm pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C1QTNF7, NEXN, and PTH1R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nucleoplasm activity versus C1QTNF7 in PDAC (Pearson r = -0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	C1QTNF7 →	-0.502	-0.191	.007	<.001	3	8
OV	NEXN →	-1.170	-0.184	<.001	.001	3	7
LSCC	PTH1R →	-0.519	-0.267	<.001	<.001	3	7
LSCC	GIMAP6 →	-0.635	-0.250	<.001	<.001	3	7
OV	CNRIP1 →	-0.796	-0.205	<.001	<.001	3	6
OV	PLXNC1 →	-0.993	-0.169	<.001	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990173 vs C1QTNF7 — PDAC

Explore this scatter interactively →