Protein localization to nucleoplasm

Across TCGA cell cohorts, RNA activity of the Protein localization to nucleoplasm pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CIART, MED25, and ZNF226, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to nucleoplasm activity versus CIART in BONE (Pearson r = -0.97).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	CIART →	-1.933	-0.336	.005	.001	3	4
BLOOD_Lymphoma	MED25 →	-0.687	-0.156	.006	.009	3	4
OESOPHAGUS	ZNF226 →	-1.580	-0.362	.001	<.001	3	3
BONE	AARS2 →	+0.623	+0.267	.009	<.001	3	3
OESOPHAGUS	DYNLL2 →	-0.560	-0.368	.007	<.001	3	3
CNS	TRIP4 →	-0.633	-0.229	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990173 vs CIART — BONE

Explore this scatter interactively →