Protein localization to site of double-strand break

Across TCGA patient cohorts, RNA activity of the Protein localization to site of double-strand break pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STAT2, TFB2M, and VASH1_S313, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to site of double-strand break activity versus STAT2 in BRCA (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STAT2 →	+0.350	+0.042	<.001	<.001	3	7
BRCA	TFB2M →	-0.483	-0.040	<.001	<.001	3	7
OV	VASH1_S313 →	+0.839	+0.050	.001	.002	3	7
OV	LIMD2 →	+0.738	+0.050	<.001	<.001	3	7
OV	NECAP2 →	+0.378	+0.069	<.001	<.001	3	7
COAD	DLD →	-0.423	-0.041	<.001	.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990166 vs STAT2 — BRCA

Explore this scatter interactively →