Protein localization to site of double-strand break

Across TCGA cell cohorts, RNA activity of the Protein localization to site of double-strand break pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C17orf75, CDC7, and TMEFF1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to site of double-strand break activity versus C17orf75 in BLOOD_Leukemia (Pearson r = 0.49).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	C17orf75 →	+0.983	+0.955	<.001	<.001	3	6
BLOOD_Lymphoma	CDC7 →	+1.244	+1.104	<.001	.004	3	6
KIDNEY	TMEFF1 →	+0.812	+1.580	.009	.005	3	5
BLOOD_Leukemia	KMT2A →	+0.872	+0.877	.001	<.001	3	5
BLOOD_Leukemia	BUD13 →	+0.650	+0.606	<.001	.004	3	5
LUNG_SCLC	UBXN1 →	+0.540	+0.229	.001	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990166 vs C17orf75 — BLOOD_Leukemia

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