Ribosome-associated ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Ribosome-associated ubiquitin-dependent protein catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GUCY1A2, HTATSF1, and ZNF598, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome-associated ubiquitin-dependent protein catabolic process activity versus GUCY1A2 in HNSC (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	GUCY1A2 →	-1.060	-0.084	<.001	<.001	3	4
UCEC	HTATSF1 →	+0.218	+0.048	<.001	.001	3	4
LSCC	ZNF598 →	+0.161	+0.049	<.001	<.001	3	4
LUAD	DDX21 →	+0.353	+0.040	.002	.005	3	4
LUAD	THOC5_S314 →	+0.491	+0.041	<.001	<.001	3	4
LUAD	BOP1 →	+0.156	+0.034	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990116 vs GUCY1A2 — HNSC

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