Ribosome-associated ubiquitin-dependent protein catabolic process

Across TCGA patient cohorts, RNA activity of the Ribosome-associated ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CBX7, TMEM8B, and RN7SL23P, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome-associated ubiquitin-dependent protein catabolic process activity versus CBX7 in OV (Pearson r = -0.32).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CBX7 →	-0.664	-0.477	<.001	<.001	3	4
CCRCC	TMEM8B →	-0.506	-0.777	<.001	<.001	3	4
OV	RN7SL23P →	-0.671	-0.251	<.001	.002	3	4
HNSC	PHF1 →	-0.534	-0.199	<.001	.007	3	4
HNSC	APBB1 →	-0.435	-0.144	.004	.005	3	4
HNSC	MECP2 →	-0.440	-0.112	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990116 vs CBX7 — OV

Explore this scatter interactively →