Ribosome-associated ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Ribosome-associated ubiquitin-dependent protein catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRIP4, ZNF598, and GFI1B, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TRIP4 grouped by Ribosome-associated ubiquitin-dependent protein catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIP4 →	-0.443	-1.220	<.001	<.001	3	10
CNS	ZNF598 →	-0.417	-1.712	<.001	<.001	3	9
LUNG_SCLC	GFI1B →	-0.315	-1.238	<.001	.001	3	5
OVARY	LTN1 →	-0.230	-1.159	.003	.001	3	5
KIDNEY	RNASEH2A →	-0.195	-1.010	.004	.006	3	5
OESOPHAGUS	KRT19 →	-0.290	-0.480	.007	<.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TRIP4 by Ribosome-associated ubiquitin-dependent protein catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →