Ribosome-associated ubiquitin-dependent protein catabolic process

Across TCGA cell cohorts, RNA activity of the Ribosome-associated ubiquitin-dependent protein catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLE3, AKNAD1, and MRPL9, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribosome-associated ubiquitin-dependent protein catabolic process activity versus TLE3 in LUNG_NSCLC_LUSC (Pearson r = 0.65).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TLE3 →	+1.369	+0.270	.005	.003	3	4
LUNG_NSCLC_LUSC	AKNAD1 →	+1.206	+0.270	.009	.003	3	4
OVARY	MRPL9 →	+0.667	+0.483	.001	.009	3	4
OESOPHAGUS	DCK →	+0.891	+0.334	<.001	<.001	3	4
SKIN	PSMD1 →	+0.386	+0.451	.003	.006	3	4
SKIN	AP3D1 →	+0.781	+0.597	.002	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990116 vs TLE3 — LUNG_NSCLC_LUSC

Explore this scatter interactively →