Response to nerve growth factor

Across TCGA patient cohorts, RNA activity of the Response to nerve growth factor pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SMOC2, SVIL_S238, and SAMSN1_S23, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nerve growth factor activity versus SMOC2 in UCEC (Pearson r = -0.20).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SMOC2 →	-0.717	-0.057	<.001	<.001	3	4
UCEC	SVIL_S238 →	-0.620	-0.062	<.001	.001	3	4
LSCC	SAMSN1_S23 →	+0.590	+0.031	.001	.002	3	4
OV	TRA2B_T33 →	-1.539	-0.057	<.001	<.001	3	4
LSCC	ARHGAP9 →	+0.415	+0.033	<.001	.002	3	4
UCEC	BUB1_S655 →	+0.777	+0.068	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990089 vs SMOC2 — UCEC

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