Response to nerve growth factor

Across TCGA patient cohorts, RNA activity of the Response to nerve growth factor pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GLRX2, ELF4, and CRX, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nerve growth factor activity versus GLRX2 in UCEC (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GLRX2 →	+0.370	+0.127	.001	.003	3	4
CCRCC	ELF4 →	-0.330	-0.169	.004	<.001	3	4
PDAC	CRX →	-0.021	-0.573	<.001	<.001	3	3
PDAC	NIT2 →	+0.229	+0.526	.001	<.001	3	3
GBM	NDUFA5 →	+0.442	+0.126	.003	.008	2	4
UCEC	CEPT1 →	+0.301	+0.189	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990089 vs GLRX2 — UCEC

Explore this scatter interactively →