Response to nerve growth factor

Across TCGA cell cohorts, RNA activity of the Response to nerve growth factor pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LIPT2, GDE1, and ADAMTS16, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LIPT2 grouped by Response to nerve growth factor-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	LIPT2 →	+0.669	+0.173	.005	.007	3	4
LUNG_NSCLC_LUSC	GDE1 →	+1.028	+0.444	<.001	.006	3	4
STOMACH	ADAMTS16 →	+1.151	+0.206	.001	<.001	3	4
STOMACH	RIC8A →	+1.457	+0.219	.003	.006	2	5
PANCREAS	RNF121 →	+0.528	+0.229	.001	.003	3	4
LARGE_INTESTINE	OTUB1 →	+0.399	+0.185	.003	.009	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LIPT2 by Response to nerve growth factor activity — BLOOD_Leukemia

Explore this box plot interactively →