Response to nerve growth factor

Across TCGA cell cohorts, RNA activity of the Response to nerve growth factor pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FOXO3, RABGAP1, and KIDINS220, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nerve growth factor activity versus FOXO3 in URINARY_TRACT (Pearson r = 0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FOXO3 →	+1.209	+0.074	<.001	.006	3	13
STOMACH	RABGAP1 →	+1.323	+0.112	<.001	<.001	3	12
STOMACH	KIDINS220 →	+1.131	+0.116	<.001	<.001	3	12
STOMACH	NCOA1 →	+1.296	+0.104	<.001	<.001	3	12
BLOOD_Lymphoma	MGA →	+0.852	+0.066	<.001	<.001	3	12
LARGE_INTESTINE	MED13 →	+0.778	+0.095	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990089 vs FOXO3 — URINARY_TRACT

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