Response to nerve growth factor

Across TCGA cell cohorts, RNA activity of the Response to nerve growth factor pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MINPP1, CEBPA, and FAM136A, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to nerve growth factor activity versus MINPP1 in BLOOD_Leukemia (Pearson r = -0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MINPP1 →	-1.316	-0.105	.001	.003	2	7
LIVER	CEBPA →	-4.923	-0.299	.003	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	FAM136A →	-0.848	-0.209	.001	.006	3	4
OVARY	DAG1 →	-0.850	-0.157	.004	.009	3	4
BLOOD_Leukemia	SPSB2 →	-0.507	-0.121	.005	.001	3	4
URINARY_TRACT	AKT3 →	+3.084	+0.415	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990089 vs MINPP1 — BLOOD_Leukemia

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