Retrograde neuronal dense core vesicle transport

Across TCGA patient cohorts, RNA activity of the Retrograde neuronal dense core vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1A, PPP1R1A, and SYT11, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde neuronal dense core vesicle transport activity versus KIF1A in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	KIF1A →	+2.223	+0.965	<.001	<.001	3	7
LSCC	PPP1R1A →	+0.458	+0.572	<.001	<.001	3	5
UCEC	SYT11 →	+0.788	+0.650	.002	<.001	3	4
LSCC	BEX5 →	+0.944	+0.628	.001	.002	3	4
LSCC	LINC00888 →	+0.593	+0.527	.007	.005	3	4
GBM	SPRY2 →	-0.656	-0.171	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990049 vs KIF1A — OV

Explore this scatter interactively →