Retrograde neuronal dense core vesicle transport

Across TCGA cell cohorts, RNA activity of the Retrograde neuronal dense core vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AP3M2, SNX15, and ENHO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retrograde neuronal dense core vesicle transport activity versus AP3M2 in LUNG_SCLC (Pearson r = 0.64).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	AP3M2 →	+1.174	+0.413	.001	<.001	3	4
LUNG_SCLC	SNX15 →	+0.951	+0.334	.005	.005	3	3
LUNG_SCLC	ENHO →	+2.159	+0.333	.003	.007	3	3
LUNG_SCLC	PLEKHH3 →	+0.993	+0.392	.006	.001	3	3
CNS	ANKRD16 →	+0.630	+0.308	.002	.003	3	3
BLOOD_Lymphoma	MCM5 →	+1.040	+0.208	.007	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990049 vs AP3M2 — LUNG_SCLC

Explore this scatter interactively →