Anterograde neuronal dense core vesicle transport

Across TCGA patient cohorts, RNA activity of the Anterograde neuronal dense core vesicle transport pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MAP2, MAP1B, and MAP2_S1155, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde neuronal dense core vesicle transport activity versus MAP2 in OV (Pearson r = 0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	MAP2 →	+0.943	+0.097	<.001	<.001	3	9
PDAC	MAP1B →	+0.269	+0.057	.003	.005	3	7
LSCC	MAP2_S1155 →	+1.504	+0.112	<.001	<.001	3	6
LSCC	MAP2_S1480 →	+1.512	+0.108	<.001	<.001	3	6
LUAD	MAP2_S833 →	+1.167	+0.098	<.001	<.001	3	6
OV	IKZF2_S433 →	-0.612	-0.056	.008	.008	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990048 vs MAP2 — OV

Explore this scatter interactively →