Anterograde neuronal dense core vesicle transport

Across TCGA patient cohorts, RNA activity of the Anterograde neuronal dense core vesicle transport pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2, RNA5SP118, and KIF1A, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Anterograde neuronal dense core vesicle transport activity versus MAP2 in LSCC (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MAP2 →	+1.606	+0.993	<.001	<.001	3	8
UCEC	RNA5SP118 →	+1.518	+0.474	<.001	.004	3	7
BRCA	KIF1A →	+1.781	+0.646	<.001	.003	2	7
LSCC	CABYR →	+1.567	+1.131	<.001	<.001	3	6
GBM	RND2 →	+0.928	+0.605	<.001	.001	3	5
LSCC	UCHL1 →	+2.285	+1.108	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990048 vs MAP2 — LSCC

Explore this scatter interactively →