Anterograde neuronal dense core vesicle transport

Across TCGA cell cohorts, RNA activity of the Anterograde neuronal dense core vesicle transport pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Ispinesib Mesylate, Enzastaurin, and Erlotinib, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Ispinesib Mesylate grouped by Anterograde neuronal dense core vesicle transport-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Ispinesib Mesylate →	+1.223	+0.456	.021	.040	3	1
BONE	Enzastaurin →	+1.250	+0.248	.021	.028	3	1
OESOPHAGUS	Erlotinib →	+0.896	+0.356	.035	.016	2	2
OESOPHAGUS	C-75 →	+0.679	+0.406	.011	.012	2	2
OESOPHAGUS	Bosutinib →	+0.675	+0.406	.042	.012	2	1
OESOPHAGUS	Afatinib →	+1.918	+0.356	.045	.016	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Ispinesib Mesylate by Anterograde neuronal dense core vesicle transport activity — BONE

Explore this box plot interactively →