Calcium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Calcium ion export across plasma membrane pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEC24D, TBC1D2B, and WAS, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion export across plasma membrane activity versus SEC24D in GBM (Pearson r = -0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SEC24D →	+0.364	+0.077	<.001	<.001	3	6
GBM	TBC1D2B →	+0.248	+0.060	<.001	<.001	3	6
GBM	WAS →	+0.584	+0.094	.001	<.001	3	6
GBM	SEPTIN1 →	+0.698	+0.073	.004	.003	3	5
GBM	ZYX_S267 →	+0.464	+0.061	<.001	<.001	3	5
OV	ATP2B1 →	+0.353	+0.067	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990034 vs SEC24D — GBM

Explore this scatter interactively →