Calcium ion export across plasma membrane

Across TCGA patient cohorts, RNA activity of the Calcium ion export across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM41A, ATP2B1, and SNHG17, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Calcium ion export across plasma membrane activity versus TMEM41A in HNSC (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TMEM41A →	+0.571	+0.201	.008	.003	3	4
LSCC	ATP2B1 →	+0.941	+0.252	<.001	<.001	3	4
GBM	SNHG17 →	+0.401	+0.104	<.001	.002	3	4
COAD	RCN2 →	+0.443	+0.200	.001	.005	3	4
LSCC	BRAFP1 →	-0.185	-0.203	.003	<.001	3	4
HNSC	ECT2 →	+0.846	+0.194	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990034 vs TMEM41A — HNSC

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