Calcium ion export across plasma membrane

Across TCGA cell cohorts, RNA activity of the Calcium ion export across plasma membrane pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ITGA2, ENPP3, and NHLH1, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ITGA2 grouped by Calcium ion export across plasma membrane-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ITGA2 →	+0.233	+1.646	.006	<.001	3	2
CNS	ENPP3 →	+0.489	+1.875	.007	<.001	3	2
OVARY	NHLH1 →	-0.246	-1.643	.003	<.001	3	1
OVARY	OR1E1 →	+0.443	+1.630	<.001	<.001	3	1
OVARY	RALYL →	+0.306	+1.703	.009	<.001	2	2
OVARY	AGPS →	+0.486	+1.630	.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ITGA2 by Calcium ion export across plasma membrane activity — OVARY

Explore this box plot interactively →