Amyloid fibril formation

Across TCGA patient cohorts, RNA activity of the Amyloid fibril formation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NID2, BCCIP, and TTC7B, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Amyloid fibril formation activity versus NID2 in OV (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NID2 →	+0.502	+0.043	.002	.002	3	6
OV	BCCIP →	-0.353	-0.042	.005	.009	3	5
GBM	TTC7B →	+0.310	+0.038	<.001	<.001	3	5
COAD	CRIP2 →	+0.543	+0.041	<.001	<.001	3	5
COAD	DDX18 →	-0.206	-0.025	<.001	<.001	3	5
LUAD	S100A13 →	+0.453	+0.026	.002	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1990000 vs NID2 — OV

Explore this scatter interactively →