Glutamatergic neuron differentiation

Across TCGA patient cohorts, RNA activity of the Glutamatergic neuron differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KLF3_S250, ZHX2, and FN3K, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Glutamatergic neuron differentiation activity versus KLF3_S250 in LSCC (Pearson r = 0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	KLF3_S250 →	+0.595	+0.098	<.001	<.001	3	5
OV	ZHX2 →	+0.387	+0.060	.005	.002	3	4
OV	FN3K →	-0.579	-0.072	.006	.001	3	4
LUAD	SHANK2_S96 →	+0.758	+0.098	.005	<.001	3	4
COAD	ZEB2 →	-0.596	-0.120	<.001	.002	3	4
LSCC	PHF2_S539 →	+0.933	+0.124	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905962 vs KLF3_S250 — LSCC

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