Glutamatergic neuron differentiation

Across TCGA cell cohorts, RNA activity of the Glutamatergic neuron differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL4R, CECR2, and IRS1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, IL4R grouped by Glutamatergic neuron differentiation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	IL4R →	-2.342	-1.394	.008	<.001	3	4
LUNG_SCLC	CECR2 →	+1.283	+0.947	.003	.008	3	4
SOFT_TISSUE	IRS1 →	-2.442	-1.122	<.001	.001	3	4
SOFT_TISSUE	ZNF81 →	-0.600	-1.130	.001	.001	3	4
LIVER	TBC1D2 →	-1.759	-1.552	.006	.006	3	4
CNS	TMEM171 →	-1.505	-1.033	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

IL4R by Glutamatergic neuron differentiation activity — LUNG_SCLC

Explore this box plot interactively →