Positive regulation of lipid localization

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipid localization pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EIF4A3, PLEKHO2, and RFC1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid localization activity versus EIF4A3 in COAD (Pearson r = -0.28).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	EIF4A3 →	-0.234	-0.027	<.001	<.001	3	8
LSCC	PLEKHO2 →	+0.362	+0.054	<.001	<.001	3	8
GBM	RFC1 →	-0.265	-0.059	<.001	<.001	3	7
LSCC	ASAH1 →	+0.540	+0.043	<.001	<.001	3	7
GBM	RRP36_S73 →	-0.715	-0.064	<.001	<.001	3	7
GBM	RSU1 →	+0.334	+0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905954 vs EIF4A3 — COAD

Explore this scatter interactively →