Positive regulation of lipid localization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NAA80, ZNF711, and MSRA, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, NAA80 grouped by Positive regulation of lipid localization-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NAA80 →	-0.823	-1.220	.008	.003	3	4
CNS	ZNF711 →	+1.295	+0.687	.006	.008	3	4
PANCREAS	MSRA →	-1.066	-0.739	.005	.006	3	4
BLOOD_Lymphoma	LAMC1 →	-1.970	-0.336	<.001	<.001	3	3
BLOOD_Lymphoma	HIC2 →	+0.727	+0.396	.003	.001	3	3
LARGE_INTESTINE	ADGRV1 →	+1.106	+0.868	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

NAA80 by Positive regulation of lipid localization activity — SOFT_TISSUE

Explore this box plot interactively →