Positive regulation of lipid localization

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LMNA, ZCCHC3, and LRRC8C, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipid localization activity versus LMNA in LUNG_NSCLC_LUAD (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	LMNA →	+0.619	+0.111	.003	.009	3	5
KIDNEY	ZCCHC3 →	-1.076	-0.163	<.001	.006	3	5
UPPER_AERODIGESTIVE_TRACT	LRRC8C →	+1.509	+0.220	.002	.002	3	4
OESOPHAGUS	FAHD2B →	-1.408	-0.224	.005	.001	3	4
SOFT_TISSUE	RPAP1 →	-0.921	-0.266	<.001	<.001	3	4
SOFT_TISSUE	EML6 →	-1.269	-0.339	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905954 vs LMNA — LUNG_NSCLC_LUAD

Explore this scatter interactively →