Regulation of lipid localization

Across TCGA patient cohorts, RNA activity of the Regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC11A1, SPP1, and RASGRP4, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of lipid localization activity versus SLC11A1 in BRCA (Pearson r = 0.18).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLC11A1 →	+0.830	+0.181	<.001	.001	3	7
COAD	SPP1 →	+2.070	+0.123	<.001	<.001	3	6
UCEC	RASGRP4 →	+0.425	+0.163	.002	.002	3	6
OV	MILR1 →	+1.034	+0.153	.001	<.001	3	6
OV	TREM1 →	+0.891	+0.169	.002	.001	3	6
COAD	F13A1 →	+1.429	+0.150	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905952 vs SLC11A1 — BRCA

Explore this scatter interactively →