Regulation of lipid localization

Across TCGA cell cohorts, RNA activity of the Regulation of lipid localization pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TICAM2, HUNK, and ZNF711, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TICAM2 grouped by Regulation of lipid localization-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	TICAM2 →	-1.133	-0.995	.001	<.001	3	4
OVARY	HUNK →	+0.940	+0.998	<.001	<.001	3	4
CNS	ZNF711 →	+1.536	+0.769	.001	.005	3	4
OVARY	FGFR2 →	+2.443	+1.005	.003	.002	3	3
UPPER_AERODIGESTIVE_TRACT	TXN →	-1.127	-1.255	.004	.003	3	3
UPPER_AERODIGESTIVE_TRACT	GLIPR1 →	-2.473	-1.365	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TICAM2 by Regulation of lipid localization activity — OVARY

Explore this box plot interactively →