Negative regulation of calcium ion import across plasma membrane

Across TCGA cell cohorts, RNA activity of the Negative regulation of calcium ion import across plasma membrane pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP3CC, PPP3CA, and SHOC2, each associated with the pathway in up to 17 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of calcium ion import across plasma membrane activity versus PPP3CC in CNS (Pearson r = 0.83).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PPP3CC →	+1.131	+0.149	<.001	<.001	3	17
SOFT_TISSUE	PPP3CA →	+1.896	+0.178	<.001	<.001	3	14
OVARY	SHOC2 →	+0.624	+0.106	.003	.002	2	13
LIVER	KCTD9 →	+1.375	+0.178	.006	.008	3	11
LUNG_NSCLC_LUSC	PPP2CB →	+1.264	+0.139	<.001	<.001	3	10
CNS	SEC24D →	+1.050	+0.084	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:1905949 vs PPP3CC — CNS

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